Mitochondrial Lon-induced mtDNA leakage contributes to PD-L1–mediated immunoescape via STING-IFN signaling and extracellular vesicles

BACKGROUND: Mitochondrial Lon is a chaperone and DNA-binding protein that functions in protein quality control and stress response pathways. The level of Lon regulates mitochondrial DNA (mtDNA) metabolism and the production of mitochondrial reactive oxygen species (ROS). However, there is little inf...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Immunother Cancer
Main Authors: Cheng, An Ning, Cheng, Li-Chun, Kuo, Cheng-Liang, Lo, Yu Kang, Chou, Han-Yu, Chen, Chung-Hsing, Wang, Yi-Hao, Chuang, Tsung-Hsien, Cheng, Shih-Jung, Lee, Alan Yueh-Luen
Formato: Artigo
Idioma:Inglês
Publicado em: BMJ Publishing Group 2020
Assuntos:
Immunotherapy Biomarkers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7713199/
https://ncbi.nlm.nih.gov/pubmed/33268351
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/jitc-2020-001372
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados