IFNα Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion

Interferon α (IFNα) is a prompt and efficient orchestrator of host defense against nucleic acids but upon chronicity becomes a potent mediator of autoimmunity. Sustained IFNα signaling is linked to pathogenesis of systemic lupus erythematosus (SLE), an incurable autoimmune disease characterized by a...

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Bibliografiska uppgifter
I publikationen:Cell Rep
Huvudupphovsmän: Gkirtzimanaki, Katerina, Kabrani, Eleni, Nikoleri, Dimitra, Polyzos, Alexander, Blanas, Athanasios, Sidiropoulos, Prodromos, Makrigiannakis, Antonis, Bertsias, George, Boumpas, Dimitrios T., Verginis, Panayotis
Materialtyp: Artigo
Språk:Inglês
Publicerad: Cell Press 2018
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6218203/
https://ncbi.nlm.nih.gov/pubmed/30355498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2018.09.001
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