Hydrogen-deuterium exchange mass spectrometry captures distinct dynamics upon substrate and inhibitor binding to a transporter

Proton-coupled transporters use transmembrane proton gradients to power active transport of nutrients inside the cell. High-resolution structures often fail to capture the coupling between proton and ligand binding, and conformational changes associated with transport. We combine HDX-MS with mutagen...

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Udgivet i:Nat Commun
Main Authors: Jia, Ruyu, Martens, Chloe, Shekhar, Mrinal, Pant, Shashank, Pellowe, Grant A., Lau, Andy M., Findlay, Heather E., Harris, Nicola J., Tajkhorshid, Emad, Booth, Paula J., Politis, Argyris
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710758/
https://ncbi.nlm.nih.gov/pubmed/33268777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20032-3
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