A proof of concept ‘phase zero’ study of neurodevelopment using brain organoid models with Vis/near-infrared spectroscopy and electrophysiology

Homeostatic control of neuronal excitability by modulation of synaptic inhibition (I) and excitation (E) of the principal neurons is important during brain maturation. The fundamental features of in-utero brain development, including local synaptic E–I ratio and bioenergetics, can be modeled by cere...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Dutta, Anirban, Karanth, Sneha Sudhakar, Bhattacharya, Mahasweta, Liput, Michal, Augustyniak, Justyna, Cheung, Mancheung, Stachowiak, Ewa K., Stachowiak, Michal K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710726/
https://ncbi.nlm.nih.gov/pubmed/33268815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77929-8
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