Monoclonal full-length antibody against TAR DNA binding protein 43 reduces related proteinopathy in neurons

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), 2 incurable neurodegenerative disorders, share the same pathological hallmark named TDP43 (TAR DNA binding protein 43) proteinopathy. This event is characterized by a consistent cytoplasmic mislocalization and aggregat...

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Detalhes bibliográficos
Publicado no:JCI Insight
Main Authors: Pozzi, Silvia, Codron, Philippe, Soucy, Geneviève, Renaud, Laurence, Cordeau, Pierre Junior, Dutta, Kallol, Bareil, Christine, Julien, Jean-Pierre
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710295/
https://ncbi.nlm.nih.gov/pubmed/33021970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.140420
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