C-type natriuretic peptide moderates titin-based cardiomyocyte stiffness

Heart failure is often accompanied by titin-dependent myocardial stiffness. Phosphorylation of titin by cGMP-dependent protein kinase I (PKGI) increases cardiomyocyte distensibility. The upstream pathways stimulating PKGI-mediated titin phosphorylation are unclear. We studied whether C-type natriure...

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Publicado en:JCI Insight
Autores principales: Michel, Konstanze, Herwig, Melissa, Werner, Franziska, Špiranec Spes, Katarina, Abeßer, Marco, Schuh, Kai, Dabral, Swati, Mügge, Andreas, Baba, Hideo A., Skryabin, Boris V., Hamdani, Nazha, Kuhn, Michaela
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Clinical Investigation 2020
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7710274/
https://ncbi.nlm.nih.gov/pubmed/33055420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.139910
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