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Mutant p53 drives the loss of heterozygosity by the upregulation of Nek2 in breast cancer cells
BACKGROUND: Mutations in one allele of the TP53 gene in early stages are frequently followed by the loss of the remaining wild-type p53 (wtp53) allele (p53LOH) during tumor progression. Despite the strong notion of p53LOH as a critical step in tumor progression, its oncogenic outcomes that facilitat...
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| Pubblicato in: | Breast Cancer Res |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7709447/ https://ncbi.nlm.nih.gov/pubmed/33267874 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13058-020-01370-y |
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