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Irradiation induces p53 loss of heterozygosity in breast cancer expressing mutant p53

Mutations in one allele of the TP53 gene in cancer early stages are frequently followed by the loss of the remaining wild-type allele (LOH) during tumor progression. However, the clinical impact of TP53 mutations and p53LOH, especially in the context of genotoxic modalities, remains unclear. Using M...

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Détails bibliographiques
Publié dans:Commun Biol
Auteurs principaux: Ghaleb, Amr, Yallowitz, Alisha, Marchenko, Natalia
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6881331/
https://ncbi.nlm.nih.gov/pubmed/31799437
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42003-019-0669-y
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