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Mutant p53 amplifies Epidermal Growth Factor Receptor family signaling to promote mammary tumorigenesis
The epidermal growth factor receptor family (ErbB2/Her2 and EGFR/ErbB1/Her1) often modulates the transcriptional program involved in promoting mammary tumorigenesis. In humans, more than 70% of ErbB2-positive sporadic breast cancers harbor p53 mutations, which correlate with poor prognosis. Also, th...
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| Udgivet i: | Mol Cancer Res |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4824060/ https://ncbi.nlm.nih.gov/pubmed/25573952 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-14-0360 |
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