Mutant p53 suppresses innate immune signaling to promote tumorigenesis

Mutant p53 (mtp53) proteins can exert cancer-promoting gain-of-function activities. We report a mechanism by which mtp53 suppresses both cell-autonomous and non-cell autonomous signaling to promote cancer cell survival and evasion of tumor immune surveillance. Mtp53 interferes with the function of t...

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Pubblicato in:Cancer Cell
Autori principali: Ghosh, Monisankar, Saha, Suchandrima, Bettke, Julie, Nagar, Rachana, Parrales, Alejandro, Iwakuma, Tomoo, van der Velden, Adrianus W. M., Martinez, Luis A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2021
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC8044023/
https://ncbi.nlm.nih.gov/pubmed/33545063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2021.01.003
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