Imaging the Met Receptor Tyrosine Kinase (Met) and Assessing Tumor Responses to a Met Tyrosine Kinase Inhibitor in Human Xenograft Mouse Models with a [(99m)Tc] (AH-113018) or Cy 5(⋆⋆) (AH-112543) Labeled Peptide

Developing an imaging agent targeting the hepatocyte growth factor receptor protein (Met) status of cancerous lesions would aid in the diagnosis and monitoring of Met-targeted tyrosine kinase inhibitors (TKIs). A peptide targeting Met labeled with [(99m)Tc] had high affinity in vitro (K(d) = 3.3 nM)...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Mol Imaging
Auteurs principaux: Jagoda, Elaine M., Bhattacharyya, Sibaprasad, Kalen, Joseph, Riffle, Lisa, Leeder, Avrum, Histed, Stephanie, Williams, Mark, Wong, Karen J., Xu, Biying, Szajek, Lawrence P., Elbuluk, Osama, Cecchi, Fabiola, Raffensperger, Kristen, Golla, Meghana, Bottaro, Donald P., Choyke, Peter
Format: Artigo
Langue:Inglês
Publié: 2015
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709139/
https://ncbi.nlm.nih.gov/pubmed/26461980
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires