Imaging the Met Receptor Tyrosine Kinase (Met) and Assessing Tumor Responses to a Met Tyrosine Kinase Inhibitor in Human Xenograft Mouse Models with a [(99m)Tc] (AH-113018) or Cy 5(⋆⋆) (AH-112543) Labeled Peptide

Developing an imaging agent targeting the hepatocyte growth factor receptor protein (Met) status of cancerous lesions would aid in the diagnosis and monitoring of Met-targeted tyrosine kinase inhibitors (TKIs). A peptide targeting Met labeled with [(99m)Tc] had high affinity in vitro (K(d) = 3.3 nM)...

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Publicado no:Mol Imaging
Main Authors: Jagoda, Elaine M., Bhattacharyya, Sibaprasad, Kalen, Joseph, Riffle, Lisa, Leeder, Avrum, Histed, Stephanie, Williams, Mark, Wong, Karen J., Xu, Biying, Szajek, Lawrence P., Elbuluk, Osama, Cecchi, Fabiola, Raffensperger, Kristen, Golla, Meghana, Bottaro, Donald P., Choyke, Peter
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7709139/
https://ncbi.nlm.nih.gov/pubmed/26461980
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