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A combined NMR and EPR investigation on the effect of the disordered RGG regions in the structure and the activity of the RRM domain of FUS

Structural disorder represents a key feature in the mechanism of action of RNA-binding proteins (RBPs). Recent insights revealed that intrinsically disordered regions (IDRs) linking globular domains modulate their capability to interact with various sequences of RNA, but also regulate aggregation pr...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Bonucci, A., Murrali, M. G., Banci, L., Pierattelli, R.
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group UK 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708983/
https://ncbi.nlm.nih.gov/pubmed/33262375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-77899-x
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