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G-quadruplex binding ability of TLS/FUS depends on the β-spiral structure of the RGG domain
The RGG domain, defined as closely spaced Arg-Gly-Gly repeats, is a DNA and RNA-binding domain in various nucleic acid-binding proteins. Translocated in liposarcoma (TLS), which is also called FUS, is a protein with three RGG domains, RGG1, RGG2 and RGG3. TLS/FUS binding to G-quadruplex telomere DNA...
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| Udgivet i: | Nucleic Acids Res |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6159513/ https://ncbi.nlm.nih.gov/pubmed/29800261 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky391 |
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