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RGG-box in hnRNPA1 specifically recognizes the telomere G-quadruplex DNA and enhances the G-quadruplex unfolding ability of UP1 domain

hnRNPA1 is a member of heteronuclear ribonucleoproteins that has been shown to promote telomere elongation apart from its roles in RNA transport and alternative splicing. It is a modular protein with an N-terminal domain called UP1 that consists of two RNA Recognition Motifs (RRM1 and RRM2 domains)...

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Detalles Bibliográficos
Publicado en:Nucleic Acids Res
Main Authors: Ghosh, Meenakshi, Singh, Mahavir
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2018
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6212785/
https://ncbi.nlm.nih.gov/pubmed/30247678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky854
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