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STAT3 Inhibitor OPB-51602 Is Cytotoxic to Tumor Cells Through Inhibition of Complex I and ROS Induction

STAT3 is a transcription factor involved in several cellular activities including inflammation, proliferation, and survival, but it also plays a non-transcriptional role in modulating mitochondrial metabolism. Given its diverse functions in human cancers, it is an emerging therapeutic target. Here w...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:iScience
मुख्य लेखकों: Brambilla, Lara, Lahiri, Tanaya, Cammer, Michael, Levy, David E.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Elsevier 2020
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708861/
https://ncbi.nlm.nih.gov/pubmed/33305182
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101822
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