Hitting the right spot: Mechanism of action of OPB‐31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)

STAT3 is a key element in many oncogenic pathways and, like other transcription factors, is an attractive target for development of novel anticancer drugs. However, interfering with STAT3 functions has been a difficult task and very few small molecule inhibitors have made their way to the clinic. OP...

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Publicado no:Mol Oncol
Main Authors: Brambilla, Lara, Genini, Davide, Laurini, Erik, Merulla, Jessica, Perez, Laurent, Fermeglia, Maurizio, Carbone, Giuseppina M., Pricl, Sabrina, Catapano, Carlo V.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5528765/
https://ncbi.nlm.nih.gov/pubmed/25777967
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molonc.2015.02.012
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