Mitochondrial dysfunction induced by a SH2 domain-targeting STAT3 inhibitor leads to metabolic synthetic lethality in cancer cells

In addition to its canonical role in nuclear transcription, signal transducer and activator of transcription 3 (STAT3) is emerging as an important regulator of mitochondrial function. Here, we demonstrate that a novel inhibitor that binds with high affinity to the STAT3 SH2 domain triggers a complex...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Genini, Davide, Brambilla, Lara, Laurini, Erik, Merulla, Jessica, Civenni, Gianluca, Pandit, Shusil, D'Antuono, Rocco, Perez, Laurent, Levy, David E., Pricl, Sabrina, Carbone, Giuseppina M., Catapano, Carlo V.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2017
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PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5488915/
https://ncbi.nlm.nih.gov/pubmed/28584133
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1615730114
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