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Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer
The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial fission and sustaining CSC expansion. These fin...
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| Gepubliceerd in: | Mol Cell Oncol |
|---|---|
| Hoofdauteurs: | , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Taylor & Francis
2019
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6736293/ https://ncbi.nlm.nih.gov/pubmed/31528704 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1644598 |
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