Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer

The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial fission and sustaining CSC expansion. These fin...

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Udgivet i:Mol Cell Oncol
Main Authors: Civenni, Gianluca, Carbone, Giuseppina M., Catapano, Carlo V.
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2019
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Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736293/
https://ncbi.nlm.nih.gov/pubmed/31528704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1644598
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