Mitochondrial fission promotes self-renewal and tumorigenic potential in prostate cancer

The emergence of therapy-resistant cancer stem cells (CSCs) limit the efficacy of prostate cancer treatment. Using genetic knockdown and chemical inhibitors, we demonstrate the critical role of Bromodomain Containing 4 (BRD4) in promoting mitochondrial fission and sustaining CSC expansion. These fin...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Mol Cell Oncol
Prif Awduron: Civenni, Gianluca, Carbone, Giuseppina M., Catapano, Carlo V.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Taylor & Francis 2019
Pynciau:
Author’s Views
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6736293/
https://ncbi.nlm.nih.gov/pubmed/31528704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2019.1644598
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