Phase I Study of OPB-31121, an Oral STAT3 Inhibitor, in Patients with Advanced Solid Tumors

PURPOSE: OPB-31121 is an oral STAT3 inhibitor with a good preclinical antitumor activity. This phase I dose-escalation study of OPB-31121 was conducted to determine maximum-tolerated dose (MTD), safety, pharmacokinetics, and preliminary antitumor efficacy in patients with advanced solid tumors. MATE...

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Detalhes bibliográficos
Publicado no:Cancer Res Treat
Main Authors: Oh, Do-Youn, Lee, Se-Hoon, Han, Sae-Won, Kim, Mi-Jung, Kim, Tae-Min, Kim, Tae-You, Heo, Dae Seog, Yuasa, Miyuki, Yanagihara, Yasuo, Bang, Yung-Jue
Formato: Artigo
Idioma:Inglês
Publicado em: Korean Cancer Association 2015
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4614199/
https://ncbi.nlm.nih.gov/pubmed/25715763
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4143/crt.2014.249
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