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Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effects

We present comboFM, a machine learning framework for predicting the responses of drug combinations in pre-clinical studies, such as those based on cell lines or patient-derived cells. comboFM models the cell context-specific drug interactions through higher-order tensors, and efficiently learns late...

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Foilsithe in:Nat Commun
Main Authors: Julkunen, Heli, Cichonska, Anna, Gautam, Prson, Szedmak, Sandor, Douat, Jane, Pahikkala, Tapio, Aittokallio, Tero, Rousu, Juho
Formáid: Artigo
Teanga:Inglês
Foilsithe: Nature Publishing Group UK 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708835/
https://ncbi.nlm.nih.gov/pubmed/33262326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19950-z
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