Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43(266-283)

BACKGROUND: Glioblastoma is the most aggressive primary brain tumour and has a very poor prognosis. Inhibition of c-Src activity in glioblastoma stem cells (GSCs, responsible for glioblastoma lethality) and primary glioblastoma cells by the peptide TAT-Cx43(266–283) reduces tumorigenicity, and boost...

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Veröffentlicht in:EBioMedicine
Hauptverfasser: Pelaz, Sara G., Jaraíz-Rodríguez, Myriam, Álvarez-Vázquez, Andrea, Talaverón, Rocío, García-Vicente, Laura, Flores-Hernández, Raquel, Gómez de Cedrón, Marta, Tabernero, María, Ramírez de Molina, Ana, Lillo, Concepción, Medina, José M., Tabernero, Arantxa
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2020
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708820/
https://ncbi.nlm.nih.gov/pubmed/33254027
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2020.103134
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