Epistasis-driven identification of SLC25A51 as a regulator of human mitochondrial NAD import

About a thousand genes in the human genome encode for membrane transporters. Among these, several solute carrier proteins (SLCs), representing the largest group of transporters, are still orphan and lack functional characterization. We reasoned that assessing genetic interactions among SLCs may be a...

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Détails bibliographiques
Publié dans:Nat Commun
Auteurs principaux: Girardi, Enrico, Agrimi, Gennaro, Goldmann, Ulrich, Fiume, Giuseppe, Lindinger, Sabrina, Sedlyarov, Vitaly, Srndic, Ismet, Gürtl, Bettina, Agerer, Benedikt, Kartnig, Felix, Scarcia, Pasquale, Noia, Maria Antonietta Di, Liñeiro, Eva, Rebsamen, Manuele, Wiedmer, Tabea, Bergthaler, Andreas, Palmieri, Luigi, Superti-Furga, Giulio
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2020
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708531/
https://ncbi.nlm.nih.gov/pubmed/33262325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19871-x
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