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Accelerated Approval or Risk Reduction? How Response Biomarkers Advance Therapeutics through Clinical Trials in Cystic Fibrosis

Progress in the development of new therapies for cystic fibrosis (CF) has benefitted from therapeutically responsive biomarkers to streamline drug development. Paradoxically, these response biomarkers have proven to be essential even in the presence of data demonstrating a lack of correlation with c...

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Pubblicato in:Trends Mol Med
Autori principali: Mayer-Hamblett, N, VanDevanter, DR
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708517/
https://ncbi.nlm.nih.gov/pubmed/32868171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molmed.2020.08.002
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