MAFB and MAF Transcription Factors as Macrophage Checkpoints for COVID-19 Severity

Defective IFN production and exacerbated inflammatory and pro-fibrotic responses are hallmarks of SARS-CoV-2 infection in severe COVID-19. Based on these hallmarks, and considering the pivotal role of macrophages in COVID-19 pathogenesis, we hypothesize that the transcription factors MAFB and MAF cr...

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Dettagli Bibliografici
Pubblicato in:Front Immunol
Autori principali: Vega, Miguel A., Simón-Fuentes, Miriam, González de la Aleja, Arturo, Nieto, Concha, Colmenares, María, Herrero, Cristina, Domínguez-Soto, Ángeles, Corbí, Ángel L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2020
Soggetti:
Immunology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708330/
https://ncbi.nlm.nih.gov/pubmed/33312178
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.603507
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