Granzyme B Expression in Visceral Adipose Tissue Associates With Local Inflammation and Glyco-Metabolic Alterations in Obesity

Granzyme B (GrB) is a serine protease produced by immune and non-immune cells, able to promote multiple processes, like apoptosis, inflammation, extracellular matrix remodeling and fibrosis. GrB expression in visceral adipose tissue (VAT) was associated with tissue damage, local inflammation and ins...

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Bibliographic Details
Published in:Front Immunol
Main Authors: Cimini, Flavia Agata, Barchetta, Ilaria, Ceccarelli, Valentina, Chiappetta, Caterina, Di Biasio, Alberto, Bertoccini, Laura, Sentinelli, Federica, Leonetti, Frida, Silecchia, Gianfranco, Di Cristofano, Claudio, Baroni, Marco Giorgio, Velotti, Francesca, Cavallo, Maria Gisella
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2020
Subjects:
Immunology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7708321/
https://ncbi.nlm.nih.gov/pubmed/33312176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.589188
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