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TINF2 is a haploinsufficient tumor suppressor that limits telomere length
Telomere shortening is a presumed tumor suppressor pathway that imposes a proliferative barrier (the Hayflick limit) during tumorigenesis. This model predicts that excessively long somatic telomeres predispose to cancer. Here, we describe cancer-prone families with two unique TINF2 mutations that tr...
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| 出版年: | eLife |
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| 主要な著者: | , , , , , , , , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
eLife Sciences Publications, Ltd
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7707837/ https://ncbi.nlm.nih.gov/pubmed/33258446 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61235 |
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