TINF2 is a haploinsufficient tumor suppressor that limits telomere length

Telomere shortening is a presumed tumor suppressor pathway that imposes a proliferative barrier (the Hayflick limit) during tumorigenesis. This model predicts that excessively long somatic telomeres predispose to cancer. Here, we describe cancer-prone families with two unique TINF2 mutations that tr...

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Bibliografiska uppgifter
I publikationen:eLife
Huvudupphovsmän: Schmutz, Isabelle, Mensenkamp, Arjen R, Takai, Kaori K, Haadsma, Maaike, Spruijt, Liesbeth, de Voer, Richarda M, Choo, Seunga Sara, Lorbeer, Franziska K, van Grinsven, Emma J, Hockemeyer, Dirk, Jongmans, Marjolijn CJ, de Lange, Titia
Materialtyp: Artigo
Språk:Inglês
Publicerad: eLife Sciences Publications, Ltd 2020
Ämnen:
Cancer Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707837/
https://ncbi.nlm.nih.gov/pubmed/33258446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.61235
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