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Structural and functional characterization of G protein–coupled receptors with deep mutational scanning
The >800 human G protein–coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of drug targets. Their myriad structural conformations and various modes of signaling make it challenging to understand their structure and fu...
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| Publicado no: | eLife |
|---|---|
| Main Authors: | , , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
eLife Sciences Publications, Ltd
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7707821/ https://ncbi.nlm.nih.gov/pubmed/33084570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54895 |
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