Structural and functional characterization of G protein–coupled receptors with deep mutational scanning

The >800 human G protein–coupled receptors (GPCRs) are responsible for transducing diverse chemical stimuli to alter cell state- and are the largest class of drug targets. Their myriad structural conformations and various modes of signaling make it challenging to understand their structure and fu...

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Dades bibliogràfiques
Publicat a:eLife
Autors principals: Jones, Eric M, Lubock, Nathan B, Venkatakrishnan, AJ, Wang, Jeffrey, Tseng, Alex M, Paggi, Joseph M, Latorraca, Naomi R, Cancilla, Daniel, Satyadi, Megan, Davis, Jessica E, Babu, M Madan, Dror, Ron O, Kosuri, Sriram
Format: Artigo
Idioma:Inglês
Publicat: eLife Sciences Publications, Ltd 2020
Matèries:
Biochemistry and Chemical Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707821/
https://ncbi.nlm.nih.gov/pubmed/33084570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.54895
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