Endogenous Cyclin D1 Promotes the Rate of Onset and Magnitude of Mitogenic Signaling via Akt1 Ser473 Phosphorylation

Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates RB and functions as a collaborative nuclear oncogene. The serine threonine kinase Akt plays a pivotal role in the control of cellular metabolism, survival, and mitogenic signaling. Herein, Akt1-mediated phosphorylation of d...

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Bibliographic Details
Published in:Cell Rep
Main Authors: Chen, Ke, Jiao, Xuanmao, Di Rocco, Agnese, Shen, Duanwen, Xu, Shaohua, Ertel, Adam, Yu, Zuoren, Di Sante, Gabriele, Wang, Min, Li, Zhiping, Pestell, Timothy G., Casimiro, Mathew C., Skordalakes, Emmanuel, Achilefu, Samuel, Pestell, Richard G.
Format: Artigo
Language:Inglês
Published: 2020
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7707112/
https://ncbi.nlm.nih.gov/pubmed/32937140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2020.108151
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