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Sexually dimorphic DNA damage responses and mutation avoidance in the mouse germline

Germ cells specified during fetal development form the foundation of the mammalian germline. These primordial germ cells (PGCs) undergo rapid proliferation, yet the germline is highly refractory to mutation accumulation compared with somatic cells. Importantly, while the presence of endogenous or ex...

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Detalhes bibliográficos
Publicado no:Genes Dev
Main Authors: Bloom, Jordana C., Schimenti, John C.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7706705/
https://ncbi.nlm.nih.gov/pubmed/33184219
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.341602.120
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