Non-Canonical and Sexually Dimorphic X Dosage Compensation States in the Mouse and Human Germline

Somatic X dosage compensation requires two mechanisms: X inactivation balances X gene output between males (XY) and females (XX), while X upregulation, hypothesized by Ohno and documented in vivo, balances X gene with autosomal gene output. Whether X dosage compensation occurs in germ cells is uncle...

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Pubblicato in:Dev Cell
Autori principali: Sangrithi, Mahesh N., Royo, Helene, Mahadevaiah, Shantha K., Ojarikre, Obah, Bhaw, Leena, Sesay, Abdul, Peters, Antoine H.F.M., Stadler, Michael, Turner, James M.A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cell Press 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5300051/
https://ncbi.nlm.nih.gov/pubmed/28132849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2016.12.023
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