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Hyperoxia sensitizes hypoxic HeLa cells to ionizing radiation by downregulating HIF-1α and VEGF expression

The current study investigated whether hyperoxia may reverse hypoxia-induced radioresistance (RR) in cervical cancer. Human HeLa cells exposed to hypoxic, normoxic or hyperoxic conditions were irradiated using X-rays. Cell proliferation and apoptosis were analyzed using MTT assays and flow cytometry...

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Detalhes bibliográficos
Publicado no:Mol Med Rep
Main Authors: Dong, Dan, Fu, Yan, Chen, Feng, Zhang, Jing, Jia, Haiyan, Li, Jia, Wang, Huailin, Wen, Jihong
Formato: Artigo
Idioma:Inglês
Publicado em: D.A. Spandidos 2021
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7706008/
https://ncbi.nlm.nih.gov/pubmed/33215223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2020.11700
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