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Digoxin Downregulates NDRG1 and VEGF through the Inhibition of HIF-1α under Hypoxic Conditions in Human Lung Adenocarcinoma A549 Cells

Digoxin, an inhibitor of Na(+)/K(+) ATPase, has been used in the treatment of heart-related diseases (such as congestive heart failure and atrial arrhythmia) for decades. Recently, it was reported that digoxin is also an effective HIF-1α inhibitor. We investigated whether digoxin could suppress tumo...

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Autori principali: Wei, Dong, Peng, Jing-Jing, Gao, Hui, Li, Hua, Li, Dong, Tan, Yong, Zhang, Tao
Natura: Artigo
Lingua:Inglês
Pubblicazione: Molecular Diversity Preservation International (MDPI) 2013
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3645685/
https://ncbi.nlm.nih.gov/pubmed/23549264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms14047273
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