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Downregulation of HIF-2α Reverse the Chemotherapy Resistance of Lung Adenocarcinoma A549 Cells to Cisplatin

BACKGROUND: Cisplatin (DDP)-based systemic chemotherapy has been widely used in the treatment of postoperative or advanced NSCLC patients, however, its effective rate is only 14~40%. HIF-2α can upregulate drug-resistant-related genes expression and lead to chemotherapy resistance in many tumors. How...

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Detalhes bibliográficos
Publicado no:Med Sci Monit
Main Authors: Gao, Zhao-jia, Yuan, Wei-dong, Yuan, Jun-qiang, Yuan, Kai, Wang, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: International Scientific Literature, Inc. 2018
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5832106/
https://ncbi.nlm.nih.gov/pubmed/29469087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.12659/MSM.906107
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