A Phase 1 Trial Assessing the Safety and Tolerability of a Therapeutic DNA Vaccination Against HPV16 and HPV18 E6/E7 Oncogenes After Chemoradiation for Cervical Cancer

PURPOSE: This study assessed the safety and tolerability of therapeutic immunization against the human papillomavirus (HPV) viral oncoproteins E6 and E7 in patients with cervical cancer after chemoradiation. METHODS AND MATERIALS: MEDI0457 (INO-3112) is a DNA-based vaccine targeting E6 and E7 of HPV...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Int J Radiat Oncol Biol Phys
Prif Awduron: Hasan, Yasmin, Furtado, Larissa, Tergas, Ana, Lee, Nita, Brooks, Rebecca, McCall, Anne, Golden, Daniel, Jolly, Shruti, Fleming, Gini, Morrow, Matthew, Kraynyak, Kimberly, Sylvester, Albert, Arif, Fauzia, Levin, Matt, Schwartz, David, Boyer, Jean, Skolnik, Jeffrey, Esser, Mark, Kumar, Rakesh, Bagarazzi, Mark, Weichselbaum, Ralph, Spiotto, Michael
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705948/
https://ncbi.nlm.nih.gov/pubmed/32151670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijrobp.2020.02.031
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