Augmentation of cellular and humoral immune responses to HPV16 and HPV18 E6 and E7 antigens by VGX-3100

We have previously demonstrated the immunogenicity of VGX-3100, a multicomponent DNA immunotherapy for the treatment of Human Papillomavirus (HPV)16/18-positive CIN2/3 in a phase 1 clinical trial. Here, we report on the ability to boost immune responses with an additional dose of VGX-3100. Patients...

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Veröffentlicht in:Mol Ther Oncolytics
Hauptverfasser: Morrow, Matthew P, Kraynyak, Kimberly A, Sylvester, Albert J, Shen, Xuefei, Amante, Dinah, Sakata, Lindsay, Parker, Lamar, Yan, Jian, Boyer, Jean, Roh, Christian, Humeau, Laurent, Khan, Amir S, Broderick, Kate, Marcozzi-Pierce, Kathleen, Giffear, Mary, Lee, Jessica, Trimble, Cornelia L, Kim, J Joseph, Sardesai, Niranjan Y, Weiner, David B, Bagarazzi, Mark L
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5147865/
https://ncbi.nlm.nih.gov/pubmed/28054033
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mto.2016.25
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