Clinical and Immunologic Biomarkers for Histologic Regression of High-Grade Cervical Dysplasia and Clearance of HPV16 and HPV18 after Immunotherapy

PURPOSE: As previously reported, treatment of high-grade cervical dysplasia with VGX-3100 resulted in complete histopatho-logic regression (CR) concomitant with elimination of HPV16/18 infection in 40.0% of VGX-3100–treated patients compared with only 14.3% in placebo recipients in a randomized phas...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Morrow, Matthew P., Kraynyak, Kimberly A., Sylvester, Albert J., Dallas, Michael, Knoblock, Dawson, Boyer, Jean D., Yan, Jian, Vang, Russell, Khan, Amir S., Humeau, Laurent, Sardesai, Niranjan Y., Kim, J. Joseph, Plotkin, Stanley, Weiner, David B., Trimble, Cornelia L., Bagarazzi, Mark L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6956401/
https://ncbi.nlm.nih.gov/pubmed/29084917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-2335
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