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Human shelterin protein POT1 prevents severe telomere instability induced by homology‐directed DNA repair

The evolutionarily conserved POT1 protein binds single‐stranded G‐rich telomeric DNA and has been implicated in contributing to telomeric DNA maintenance and the suppression of DNA damage checkpoint signaling. Here, we explore human POT1 function through genetics and proteomics, discovering that a c...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Glousker, Galina, Briod, Anna‐Sophia, Quadroni, Manfredo, Lingner, Joachim
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705456/
https://ncbi.nlm.nih.gov/pubmed/33073402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020104500
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