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Gallic acid is a dual α/β-secretase modulator that reverses cognitive impairment and remediates pathology in Alzheimer mice

Several plant-derived compounds have demonstrated efficacy in pre-clinical Alzheimer's disease (AD) rodent models. Each of these compounds share a gallic acid (GA) moiety, and initial assays on this isolated molecule indicated that it might be responsible for the therapeutic benefits observed....

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Foilsithe in:J Biol Chem
Main Authors: Mori, Takashi, Koyama, Naoki, Yokoo, Tomotaka, Segawa, Tatsuya, Maeda, Masahiro, Sawmiller, Darrell, Tan, Jun, Town, Terrence
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Biochemistry and Molecular Biology 2020
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705308/
https://ncbi.nlm.nih.gov/pubmed/32913125
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA119.012330
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