Lkb1 suppresses amino acid-driven gluconeogenesis in the liver

Excessive glucose production by the liver is a key factor in the hyperglycemia observed in type 2 diabetes mellitus (T2DM). Here, we highlight a novel role of liver kinase B1 (Lkb1) in this regulation. We show that mice with a hepatocyte-specific deletion of Lkb1 have higher levels of hepatic amino...

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Udgivet i:Nat Commun
Main Authors: Just, Pierre-Alexandre, Charawi, Sara, Denis, Raphaël G. P., Savall, Mathilde, Traore, Massiré, Foretz, Marc, Bastu, Sultan, Magassa, Salimata, Senni, Nadia, Sohier, Pierre, Wursmer, Maud, Vasseur-Cognet, Mireille, Schmitt, Alain, Le Gall, Morgane, Leduc, Marjorie, Guillonneau, François, De Bandt, Jean-Pascal, Mayeux, Patrick, Romagnolo, Béatrice, Luquet, Serge, Bossard, Pascale, Perret, Christine
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7705018/
https://ncbi.nlm.nih.gov/pubmed/33257663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19490-6
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