Simultaneous profiling of chromatin accessibility and methylation on human cell lines with nanopore sequencing

Probing epigenetic features on DNA has tremendous potential to advance our understanding of the phased epigenome. In this study, we use nanopore sequencing to evaluate CpG methylation and chromatin accessibility simultaneously on long strands of DNA by applying GpC methyltransferase to exogenously l...

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Publicat a:Nat Methods
Autors principals: Lee, Isac, Razaghi, Roham, Gilpatrick, Timothy, Molnar, Michael, Gershman, Ariel, Sadowski, Norah, Sedlazeck, Fritz J., Hansen, Kasper D., Simpson, Jared T., Timp, Winston
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704922/
https://ncbi.nlm.nih.gov/pubmed/33230324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-020-01000-7
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