NitroSynapsin ameliorates hypersynchronous neural network activity in Alzheimer hiPSC models

Beginning at early stages, human Alzheimer’s disease (AD) brains manifest hyperexcitability, contributing to subsequent extensive synapse loss, which has been linked to cognitive dysfunction. No current therapy for AD is disease-modifying. Part of the problem with AD drug discovery is that transgeni...

詳細記述

保存先:
書誌詳細
出版年:Mol Psychiatry
主要な著者: Ghatak, Swagata, Dolatabadi, Nima, Gao, Richard, Wu, Yin, Scott, Henry, Trudler, Dorit, Sultan, Abdullah, Ambasudhan, Rajesh, Nakamura, Tomohiro, Masliah, Eliezer, Talantova, Maria, Voytek, Bradley, Lipton, Stuart A.
フォーマット: Artigo
言語:Inglês
出版事項: 2021
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7704704/
https://ncbi.nlm.nih.gov/pubmed/32467645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41380-020-0776-7
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