Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

Parkinson’s disease is characterized by accumulation of α-synuclein (αSyn). Release of oligomeric/fibrillar αSyn from damaged neurons may potentiate neuronal death in part via microglial activation. Heretofore, it remained unknown if oligomeric/fibrillar αSyn could activate the nucleotide-binding ol...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Trudler, Dorit, Nazor, Kristopher L., Eisele, Yvonne S., Grabauskas, Titas, Dolatabadi, Nima, Parker, James, Sultan, Abdullah, Zhong, Zhenyu, Goodwin, Marshall S., Levites, Yona, Golde, Todd E., Kelly, Jeffery W., Sierks, Michael R., Schork, Nicholas J., Karin, Michael, Ambasudhan, Rajesh, Lipton, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054017/
https://ncbi.nlm.nih.gov/pubmed/33833060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025847118
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