Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

Parkinson’s disease is characterized by accumulation of α-synuclein (αSyn). Release of oligomeric/fibrillar αSyn from damaged neurons may potentiate neuronal death in part via microglial activation. Heretofore, it remained unknown if oligomeric/fibrillar αSyn could activate the nucleotide-binding ol...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Trudler, Dorit, Nazor, Kristopher L., Eisele, Yvonne S., Grabauskas, Titas, Dolatabadi, Nima, Parker, James, Sultan, Abdullah, Zhong, Zhenyu, Goodwin, Marshall S., Levites, Yona, Golde, Todd E., Kelly, Jeffery W., Sierks, Michael R., Schork, Nicholas J., Karin, Michael, Ambasudhan, Rajesh, Lipton, Stuart A.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2021
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC8054017/
https://ncbi.nlm.nih.gov/pubmed/33833060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2025847118
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