Alternative AKT2 splicing produces protein lacking the hydrophobic motif regulatory region

Three AKT serine/threonine kinase isoforms (AKT1/AKT2/AKT3) mediate proliferation, metabolism, differentiation and anti-apoptotic signals. AKT isoforms are activated downstream of PI3-kinase and also by PI3-kinase independent mechanisms. Mutations in the lipid phosphatase PTEN and PI3-kinase that in...

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Publicat a:PLoS One
Autors principals: Plotz, Guido, Lopez-Garcia, Laura A., Brieger, Angela, Zeuzem, Stefan, Biondi, Ricardo M.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703976/
https://ncbi.nlm.nih.gov/pubmed/33253205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0242819
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