Cocaine vaccine dAd5GNE protects against moderate daily and high-dose “binge” cocaine use

The cocaine vaccine dAd5GNE is comprised of a disrupted serotype 5 adenovirus gene therapy vector covalently conjugated to the cocaine analog GNE. The vaccine evokes a high titer of circulating anti-cocaine antibodies that prevent cocaine from reaching its cognate receptors in the central nervous sy...

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Bibliographic Details
Published in:PLoS One
Main Authors: Havlicek, David F., Rosenberg, Jonathan B., De, Bishnu P., Hicks, Martin J., Sondhi, Dolan, Kaminsky, Stephen M., Crystal, Ronald G.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703925/
https://ncbi.nlm.nih.gov/pubmed/33253224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0239780
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