Cardiomyocyte Oga haploinsufficiency increases O-GlcNAcylation but hastens ventricular dysfunction following myocardial infarction

RATIONALE: The beta-O-linkage of N-acetylglucosamine (i.e., O-GlcNAc) to proteins is a pro-adaptive response to cellular insults. To this end, increased protein O-GlcNAcylation improves short-term survival of cardiomyocytes subjected to acute injury. This observation has been repeated by multiple gr...

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Pubblicato in:PLoS One
Autori principali: Dassanayaka, Sujith, Brittian, Kenneth R., Long, Bethany W., Higgins, Lauren A., Bradley, James A., Audam, Timothy N., Jurkovic, Andrea, Gumpert, Anna M., Harrison, Linda T., Hartyánszky, István, Perge, Péter, Merkely, Béla, Radovits, Tamás, Hanover, John A., Jones, Steven P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2020
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7703924/
https://ncbi.nlm.nih.gov/pubmed/33253217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0242250
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